The AD1362 is a complete, precision 16-channel data acquisition system. The device contains two 8-channel multiplexers, a differential amplifier, a sample-and-hold with high-speed output amplifier, a channel address latch and control logic. The multiplexers may be connected to the differential amplifier in either an 8-channel differential or 16-channel single-ended configuration. A unique feature of the AD1362 is an internal user-controllable analog switch that connects the multiplexers in either a single-ended or differential switch that connects the multiplexers in either a single-ended or differential mode. This allows a single device to perform in either mode without hard-wire programming and permits a mixture of single-ended and differential sources to be interested by dynamically switching the input mode control.